TEAM

Cancer treatment currently requires the joint efforts of a multidisciplinary team. The alternatives for treatment are constantly expanding. With the use of new effective chemotherapy, hormone therapy, and biological agents and with information regarding more effective ways to integrate systemic therapy, surgery, and radiation therapy, elaborating an appropriate treatment plan is becoming more complex. Developing such a plan should be based on knowledge of the benefits and potential acute and late toxic effects of each of the therapy regiments. Despite advances in early detection and understanding of the molecular bases of cancer biology, many patients with early-stage cancer have recurrent disease, which is metastatic in most cases. To offer better treatment with increased efficacy and low toxicity, selecting therapies based on the patient and the clinical and molecular characteristics of the tumor is necessary.

Only teams that have a clear translation to the clinic and aim to resolve a social and medical problem have the chance to reach their goal. And nanoDRUG unity is one of them. The reason behind is because this unity combines four disciplines in a unique, single consortium that together enable the search of novel therapies for cancer: Chemists and Nanotechnologists to generate novel medicines and nanomedicines nanodevices, Cellular biologists from identification of mechanisms of resistance and targeted combinations to efficient clinical drug development and Pharmacologists to develop preclinical studies of the drugs generated.

unidadnanodrug
carlos_alonso_UCLM
Carlos Alonso Moreno

Carlos was born in 1978 outside Ciudad Real, Spain. In 2000, he earned his Bachelor of Science in Chemistry from the University of Castilla-La Mancha. Alonso-Moreno earned his Ph.D. with Professor Antonio Antiñolo at University of Castilla-La Mancha in 2005 for his dissertation on metallocene catalyzed olefin polymerization. After a two-year postdoctoral appointment with Professor Manfred Bochmann at the School of Pharmacy in the University of East-Anglia, United Kingdom, and a short brief of one-year at the University of Rey Juan Carlos, Spain, Alonso-Moreno began his independent career at University of Castilla-La Mancha in 2008. In 2010, he was promoted to Associate Professor and in 2018 was named Professor of Inorganic Chemistry at the School of Pharmacy in the University of Castilla-La Mancha, Spain, in which he was Vice-dean (2012–2017). His research has been mainly involved in the design and development of new organometallic entities as efficient catalysis to produce biodegradable polymers. Today, he is mainly interested in the application of the tailor-made polymeric macrostructures in oncology by the generation of nanodevices.

ORCID: 0000-0002-7588-0781

Scopus Author ID: 8613316700

ResearcherID: K-2087-2014

Google Scholar: https://scholar.google.es/citations?user=Lq7zDPkAAAAJ&hl=es

ivan_bravo_uclm
Iván Bravo Pérez

ivan.bravo@uclm.es

ORCiD: https://orcid.org/0000-0003-1589-5399

Researchgate: https://www.researchgate.net/profile/Ivan-Bravo-3

Scholar Google: https://scholar.google.es/citations?user=bUTCR6wAAAAJ&hl=es

Graduate and PhD in Chemistry from the University of Castilla-La Mancha (UCLM). Assistant Professor at the UCLM Faculty of Pharmacy teaching Physical Chemistry applied to the Pharmaceutical field in areas such as Transport and Surface Phenomena, Chemical Kinetics or Photophysics applied to Biological systems.

He is currently developing lines of research at the Faculty of Pharmacy focused on the design of new fluorescent biosensors for FLIM microscopy; Nanotechnology applied for the development, distribution and monitoring of drugs; and Design of new fluorescent materials for biomedical and therapeutic applications.

alberto_ocana
Alberto Ocaña Fernández

alberto.ocana@salud.madrid.org

ORCiD: https://orcid.org/0000-0003-1589-5399

Scopus Author ID: 12776104000

Scholar Google: https://scholar.google.com/citations?user=Jvw49z0AAAAJ&hl=es

Oncologist scientist, leading the Experimental Therapeutics Unit, at the Hospital Clínico San Carlos in Madrid, Spain. He trained in Molecular Biology at Vall d´Hebron Hospital, Barcelona and in Drug Development and Design of Clinical studies at Princess Margaret Hospital in Toronto, Canada. He has also been a visiting professor at Yale University. Dr Ocana has more than 180 published articles in scientific journals.

 

cristina_martin
Cristina Martín Álvarez

cristina.malvarez@uclm.es

ORCiD: 0000-0002-7588-8759

Scopus Author ID: 57212178634

Researchgate: https://www.researchgate.net/profile/Cristina-Martin-Alvarez

Google Scholar: https://scholar.google.com/citations?user=DKADKSIAAAAJ&hl=nl&oi=ao

Cristina received her bachelor’s degree in chemistry at the University Complutense of Madrid (UCM) in 2009. In 2015, she got her PhD degree in Nanoscience and Nanotechnology at the University of Castilla-la Mancha (UCLM) under the supervision of Prof. Douhal and Prof. Cohen. She continued her career as a postdoctoral student with the group of Prof. Hofkens at KU Leuven (2015-2019). Since 2019 she joins FOTOAIR group at UCLM University as an associated professor.

Her research interest has been mainly focused on how different time-resolved and single-molecule spectroscopic tools can help to unravel the working mechanism of new designed and synthesized materials with the aim of improving their properties in different fields as optoelectronic devices, catalyst, optical sensors, or drug delivery.

Besides the developed research lines, she gave theoretical and practical classes in Ciencias del Medio Ambiente, Bioquímica and Farmacia at UCLM as well as in the Bioscience Engineering and Biophysics, Biochemistry and Biotechnology at KU Leuven University.

 

Almudena del Campo Balguerías
Almudena del Campo Balguerías

almudena.delcampo@uclm.es

ORCiD: 0000-0002-0119-6733

Almudena was graduated in Pharmacy in 2021. After finishing her degree, she got an internship in the KU Leuven University, Belgium. There she worked in a research project in the Molecular Imaging and Photonics lab, where her interest in pursuing science really took shape.

Just a few months later, she obtained a grant to start her PhD in the Department of Inorganic Chemistry at Castilla-La Mancha University. She is currently working in the search for new therapeutic agents as an alternative for the treatment of cancer, as well as in the design of nanovehicles to encapsulate them with the goal of enhance its properties.

Cristina Blasco Navarro
Cristina Blasco Navarro

cristina.blasco2@alu.uclm.es

ORCiD:

Cristina has recently been graduated in Pharmacy. In 2021, she received a scholarship from Spanish Association Against Cancer (AECC) to carry out a research project at Pharmacy School in Albacete. Afterwards, in 2022 during the last year of her bachelor she also obtained a grant from University of Castilla-La Mancha to design new nanovehicles to encapsulate antitumor drugs.

She is currently doing an internship in NOVA School of Science and Technology in Lisbon where she is learning about different materials for the synthesis of nanovehicles.

María Arenas Moreira
María Arenas Moreira

Mariagracia.arenas@uclm.es

ORCiD: 0000-0003-4112-669X

María was graduated in Pharmacy (2021) at University of Castilla-La Mancha. She is currently a PhD student at the same University, funded by ACEPAIN (Asociación Costuras en la Piel en Apoyo a la investigación de cáncer en Albacete).

During her bachelor she acquired undergraduate research experience in Inorganic Chemistry, Physical Chemistry and Nanotechnology, complemented by an internship in Twente University (The Netherlands) once she was graduated.

Currently, her research is based on the development of new nanosystems to enhance the activity of new antitumor drugs.

 

Diego Herrera Ochoa
Diego Herrera Ochoa

Diego.Herrera@uclm.es

ORCiD: 0000-0002-3870-4113

Diego is a PhD student at University of Castilla-La Mancha in the Department of Physical Chemistry of Pharmacy School in Albacete. In 2018 he obtained his BSc. in Biology at University of Jaén. The next year, he got his MSc in Biotechnology and Biomedicine at the same University. He is working in the development of sensors which measure intracellular pH by fluorescence lifetime imaging microscopy (FLIM).

Currently, he is doing an internship at KU Leuven University (Belgium), where he is testing his sensors in 3D cell culture.

Sofía Blas Gómez
Sofía Blas Gómez

sofia.blas@alu.uclm.es

Sofía is a fifth-grade student of Pharmacy. In 2021 she was employed by Spanish Association Against Cancer (AECC) thanks to a research scholarship. Afterwards, in 2022 she also got a research contract during summer period.

To sum up, although her youth she has a curious mind which drives her into the wonders of laboratory investigations.

Sofía Blas Gómez
Andrés Garzón Ruiz

Andrés Garzón Ruiz is Graduated in Chemistry from the University of Jaén and Doctor in Chemistry from the University of Castilla-La Mancha. Lecturer at the Faculty of Pharmacy from the University of Castilla-La Mancha since July 2010. He has researched in diverse fields of Physical Chemistry, particularly fluorescence spectroscopy and microscopy applied to Pharmacy and Biomedicine. His current research lines are focused on the development of fluorescent probes for biological systems (employing FLIM: Fluorescence Lifetime Imaging Microscopy) and the study of drug-protein interactions using various fluorescence spectroscopy techniques. He is also involved in other projects aimed at unraveling the photophysics of fluorophores with biological and biomedical applications. 

Sofía Blas Gómez
M. Consuelo Ripoll Lorente

Consuelo was born in Granada, Spain. In 2014, she obtained her B.Sc. degrees in Biology and Biochemistry from the University of Granada. In 2015, she completed the Master “Investigación, Desarrollo, control e innovación de medicamentos”, where she started her relationship with research, publishing a high impact scientific article with her master thesis. Consuelo obtained her Ph.D at the University of Granada in 2019 for her dissertation entitled: “Metabolic nanosensor for the identification of tumoral metabophenotypes”. During 2019-2020, she did a postdoctoral stay at the Instituto andaluz de ciencias de la tierra, CSIC.

In 2021, she joined the Department of Physicochemistry of the Faculty of Pharmacy of Albacete, UCLM, with a postdoctoral fellowship, where she is working with cellular nanosensors monitored with fluorescence lifetime microscopy, FLIM.

Sofía Blas Gómez
José Antonio Castro-Osma

José Antonio Castro-Osma is a lecturer at the School of Pharmacy of the Universidad de Castilla-La Mancha. After completing his PhD studies at the Universidad de Castilla-La Mancha in 2013 under the supervision of Prof. Antonio Otero and Dr. Agustín Lara-Sánchez, he completed a postdoctoral position with Prof. Michael North at the Green Chemistry Centre of Excellence at the University of York. His current research is focused on the development of new catalytic processes for the transformation of CO2 and biomass-derived chemical feedstocks into high-value added chemical products and polymers.

Sofía Blas Gómez
Felipe de la Cruz Martínez

Felipe de la Cruz-Martínez was born in Badajoz (Spain) in 1990. He studied chemistry at University of Extremadura where he began his career research working on the design of anticancer agents. Then, he moved at the University of Castilla-La Mancha where he completed his PhD studies on the carbon dioxide utilization for the synthesis of industrial valuable products under the supervision of Prof. Agustín Lara-Sánchez and Dr. José A. Castro-Osma. He also did a PhD stay at the University of York under the supervision of Prof. Michael North focused on the synthesis of CO2-based hydroxyurethanes. In 2021, he joined Dr. Jesús Campos group as a postdoctoral fellow working on the development of bimetallic pairs for the activation of small molecules. Since September 2022, he is based at the University of Castilla-La Mancha as an Assistant Professor.

Sofía Blas Gómez
Irene Sevilla Carrillo

Irene was born in 2000 in a village near Cuenca, Spain. She is a recent graduate in Biochemistry from the University of Castilla-La Mancha. In her Bachelor Thesis she investigated organometallic complexes as possible anti-tumour agents and also won the prize of the informative contest “Tu TFG en 3 minutos”. In the summer of 2022, she spent a stay at KU Leuven, where she worked on the internalisation of nanoparticles in 2D and 3D cellular models. In the next academic year, she will be in Albacete doing the Master in Experimental Biomedicine together with Alonso-Moreno’s group.

Sofía Blas Gómez
Almudena Ruiz García

Técnico de apoyo a la docencia y a la investigación

almudena.ruiz@uclm.es

ORCID:

https://orcid.org/0000-0001-6326-9937

Graduated in Biology from the University of Valencia in 2005. In 2007 she joined Dr. Laborda´s laboratory as a PhD student under the supervision of Dr. Laborda and Dra. Díaz-Guerra to study the role of Notch proteins in macrophage activation. During that time, she published several works focused on the analysis of the glucose metabolic changes, associated with classical and alternative macrophage activation pathways. In 2012 she got a PhD in Experimental Biomedicine from the Castilla-La Mancha University (UCLM).

Since 2017 she works as a I+D technician at the UCLM Faculty of Pharmacy, to support the nanodrug group, led by Dr. Carlos Alonso Moreno.

 

Sofía Blas Gómez
Rosario Sánchez Muñoz

Rosario obtained her FP1 certification (laboratory operations technician) in 2021. In the NanoDrug laboratory she has carried out research work handling UV-Vis spectroscopy techniques, characterization of nanostructures, releasing profiles of nanodevices, Fluorescence spectroscopy, dynamic light scattering techniques; as well as FLIM Microscopy techniques. Training in the field of Nanotechnology applied to cancer treatment.

Currently she is a research technician funded by ACEPAIN (Asociación Costuras en la Piel en Apoyo a la investigación de cáncer en Albacete), in charge of assisting the various projects carried out in our laboratories.

Sofía Blas Gómez
Elena Domínguez Jurado

Elena studied pharmacy at the University of Castilla-La Mancha. During those years she obtained several scholarships with which she was able to start her work in cancer research. After graduating in 2020, she got a contract with the University of Castilla-La Mancha to start her doctoral thesis in the area of inorganic chemistry.

Currently his research is based on the synthesis of new antitumor compounds as an alternative to existing drugs, as well as the development of nanoformulations that improve the activity of these compounds.

Sofía Blas Gómez
Daniel Hermida Merino

ORCID: https://orcid.org/0000-0002-8181-158X 

Researchgate: https://www.researchgate.net/profile/Daniel-Hermida-Merino 

I received the Master of Science in Physical Chemistry at the University of Vigo and I then completed a PhD in supramolecular polymers at Reading University. I then joined the ESRF as a post-doctoral fellow from Eindhoven Technical University first and then from Dutch Polymer Institute (DPI) to promote the research of polymer materials under processing conditions. Thereafter, I was promoted to beamline scientist responsible for the Dutch-Belgium SAXS/WAXS beamline (BM26b) at ESRF until I have been awarded the Maria Zambrano grant to join the University of Vigo as a researcher. The focus of my research is mainly aimed at the structure-properties relationship in the area of polymer physics, particularly the characterization of advanced polymeric materials in bulk, solution and thin films using a wide range of physical techniques. I have comprehensive experience in soft matter including polymer crystallization, polymer processing under industrial conditions and supramolecular self-assembly. In addition, my scientific projects are driven to advance in the design of novel functional polymeric materials with tailored properties with particular emphasis, on the use of green approaches and the generation of biocompatible materials featuring nanomedicine applications mainly due to the increase of societal demands for bioenvironmental policies.